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Welcome to the Groves Lab
Department of Chemistry
Princeton University


 

The Groves Group (2009)
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The major thrust of our research program is at the interface of organic, inorganic, and biological chemistry. Many biochemical transformations as well as important synthetic and industrial processes are catalyzed by metals. Current efforts focus on understanding the mechanisms of metalloproteins, the design of new, biomimetic catalysts and the molecular mechanisms of these processes, studies of host-pathogen interactions related to iron acquisition by small molecule siderophores and molecular probes of the role of peroxynitrite in biological systems.

Group News

 

October 2009. Congratulations to Prof. Groves on receiving the 2010 Hans Fischer Career Award in Porphyrin Chemistry. This award is given every two years to a senior scientist for his accomplishments in the field of porphyrin-related bioinorganic chemistry. The award comes from the Society of Porphyrins and Phthalocyanines. It is sponsored by the Hans Fischer Gesellschaft in Munich, named for the German organic chemist who received the 1930 Nobel Prize in Chemistry. Prof. Groves will be presented with the award at the International Conference on Porphyrins and Phthalocyanines in July 2010 in Santa Ana Pueblo, New Mexico.

 

August 2009. Congratulations to Basak Surmeli on defending her doctoral thesis. Basak has accepted a postdoctoral research position with Prof. Mike Marletta at UC Berkeley.

 

August 2009. Congratulations to Jia Su on the acceptance of her paper. Jia's paper, entitled "Direct Detection of the Oxygen Rebound Intermediates, Ferryl Mb and NO2, in the Reaction of metMyoglobin with Peroxynitrite," has been accepted for publication in the Journal of the American Chemical Society.

 

June 2009. Congratulations to Seth Bell on the acceptance of his paper. Seth's paper, entitled "A Highly Reactive P450 Model Compound I," has been accepted for publication in the Journal of the American Chemical Society.

 

June 2009. Congratulations to James Yan on his graduation. James will be beginning doctoral work in chemistry at Stanford University this fall.

April 2009. Congratulations to Prof. Groves on being named a Fellow of the Royal Society of Chemistry. The honor comes from one of the largest organizations in Europe working to advance the chemical sciences. Fellows are elected annually in recognition of their outstanding contributions to the field of chemistry. Also named this year from our department is Prof. Roberto Car.

March 2009. Congratulations to Jyoti Tibrewala on her first place poster prize. Jyoti's poster "Therapeutic Applications of Biomimetic Catalysis: Synthetic Porphyrins to Decompose Peroxynitrite" placed first out of 28 entries in the student poster competition at the 2009 Spring Symposium of the Catalysis Society of Metropolitan New York. She has also been invited to speak at an upcoming meeting of the Catalysis Society.

January 2009. Congratulations to Chris Bergstrom on receiving the Eli Lilly Graduate Student Fellowship. This fellowship is awarded each spring to a top graduate student working in a field with medical applications.

 

November 2008. Congratulations to Courtney McQueen on her poster's honorable mention. Courtney's poster "Host-Pathogen Interactions: the Effects of Siderophores on Macrophage Cellular Metabolism" received an honorable mention at the 2008 Princeton Research Symposium.

 

August 2008. Congratulations to Jia Su on her thesis defense. Jia has accepted a postdoctoral research position at Regeneron Pharmaceuticals.

 

May 2008. Congratulations to Courtney McQueen on being named a 2008 Bristol Meyers Squibb Fellow. This summer fellowship is awarded each year to top graduate students in organic synthesis. Courtney was also the recipient of a Pickering Teaching Award, awarded each year to superb teaching assistants.

 

May 2008. Congratulations to Jyoti Tibrewala on receiving the 2008 Merck-Patchett Summer Fellowship. Named for former Merck Vice President Arthur Patchett '51, this fellowship is awarded each spring to a top organic chemistry student.

May 2008. Congratulations to Prof. Groves on receiving the 2009 Frontiers in Biological Chemistry Award. The award is given by the Max Planck Institute for Bioinorganic Chemistry in Mulheim an der Ruhr, Germany. Established in 1995, the award honors an internationally renowned scientist in either bioinorganic chemistry or biological photochemistry. The awardees are invited to present a series of lectures, culminating in a special award lecture to a general audience. Previous awardees include Brian Hoffman (2007) and Harry Gray (2006).

 

February 2008. Congratulations to Prof. Groves on receiving the 2008 "Grand Prix de la Fondation de la Maison de la Chimie." The award is given every other year "...honoring an original work in Chemistry of benefit to mankind, society or nature." They have cited Prof. Groves's work with cytochrome P450 enzymes and model metalloporphyrin catalysts. He will share the prize with Jean-Pierre Maffrand, former head of Drug Discovery at Sanofi-Aventis, who discovered clopidogrel (Plavix) the anti-platelet aggregation drug. The connection is that Plavix becomes activated in the body by the actions of cytochrome P450 enzymes for which Jay and his group had determined the chemical mechanism. Recent winners of this prize have been Jerry Meinwald and Tom Eisner (2006), Neil Bartlett (2004) and Henri Kagan and Hisashi Yamamoto (2002). The 2008 laureates were announced in Paris in February.

Alumni News

Ankona Datta, currently a postdoctoral research associate with Prof. Ken Raymond at UC Berkeley, has accepted a position as Assistant Professor of Chemistry at the Tata Institute of Technology in Mumbai, India, beginning in 2010.

Melanie Sanford, Associate Professor of Chemistry at the University of Michigan, has received the BASF Catalysis Award for 2009 and the ACS Arthur C. Cope Scholar Award for 2008. Recent work from the Sanford lab has appeared on the cover of JACS 2009, showing two mechanistically distinct pathways for the reductive elimination from Pd(IV) complexes to form carbon-oxygen and carbon-carbon bonds.

Minkui Luo was appointed Assistant Member and Laboratory Head at the Sloan-Kettering Research Institute in New York in fall 2008.

Anthony Sauve was promoted to Associate Professor in the Department of Pharmacology at the Weill Cornell Medical College in New York in spring 2008.

Michael Stern was appointed President of Monsanto's American Seeds division in 2008.

Yoshi Watanabe has been appointed Vice President (Provost) of the University of Nagoya.

Prof. John T. Groves: e-mail jtgroves@princeton.edu

 

 

 

 

 

 

 

 

 

 

 

 

Last updated: 10/1/2009

     Questions & Suggestions: email Jyoti Tibrewala

 

 

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