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Saville Lectures

Dudley A. Saville
Dudley A. Saville

In memory of our colleague, Princeton University’s Department of Chemical Engineering has established the Dudley A. Saville Lectureship for exceptional early-career chemical engineers and scientists. Inspired by his family and colleagues, this series reflects Dudley Saville’s longtime association with Princeton, his uncompromising pursuit of excellence, and his commitment to helping young people begin their academic careers. In his nearly 40 years at Princeton University, he pioneered new directions in fluid mechanics, especially electrohydrodynamics. Although Dudley’s emphasis was always on fundamentals, the practical applications of his research spanned protein crystallization, electrohydrodynamic printing, enhanced oil recovery, patterning of colloidal crystals, and fluid behavior in microgravity, including an experiment flown on the Space Shuttle Columbia.

Dudley was also a pillar supporting the department’s educational mission. Whether teaching thermodynamics, fluid mechanics, engineering mathematics, or transport phenomena, his classes were distinguished by their mathematical rigor and clarity of exposition. A demanding instructor, he earned the respect of generations of chemical engineering students.

In 1997, he received the Alpha Chi Sigma Award from the American Institute of Chemical Engineers; in 2001, he was named the Stephen C. Macaleer ’63 Professor in Engineering and Applied Science; and in 2003 he was elected to the National Academy of Engineering, the highest professional recognition for an American engineer.

2016 Saville Lecturer: Arthi Jayaraman

Arthi Jayaraman received her B.E (Honors) degree in Chemical Engineering from Birla Institute of Technology and Science, Pilani, India in 2000. She received her Ph.D. in Chemical and Biomolecular   Engineering from North Carolina State University in 2006, and from 2006-2008 conducted her postdoctoral research in the department of Materials Science and Engineering at University of Illinois-Urbana Champaign. In August 2008 she joined the faculty of the Department of Chemical and Biological Engineering at University of Colorado at Boulder, and held the position of Patten Assistant Professor. In August 2014 she joined the faculty at the University of Delaware as Associate professor of Chemical and Biomolecular Engineering and Materials Science and Engineering. She has received the AIChE COMSEF division young investigator award (2013), ACS PMSE division young investigator recognition (2014), University of Colorado Provost Faculty Achievement Award (2013), Department of Energy (DOE) Early Career Research Award (2010), ACS Women Chemists Committee Lectureship Award, the University of Colorado outstanding undergraduate teaching award (2011) and graduate teaching award (2014) in Chemical and Biological Engineering. Her research expertise lies in development of theory and simulation techniques and application of these techniques to study polymer functionalized nanoparticles and polymer nanocomposites, and to design polymers for gene delivery and biomedical applications.

Theory and Simulations of Macromolecular Soft Materials: Linking Molecular Design to Macroscale Morphology and Function

Arthi Jayaraman, University of Delaware

Location:  Friend Center Convocation Room, FC113  
Date:       March 23, 2016  
Time:       4:00 PM  

We develop and use theory and simulation techniques to connect molecular features of macromolecular materials, specifically polymers, to their morphology and macroscopic properties, thereby guiding synthesis of materials for various applications in the energy and biomedical fields.

In the first part of my talk I will present our recent theory and simulation studies of polymer functionalized nanoparticles in polymer nanocomposites. The goal of this work is to control spatial arrangement of nanoparticles in a polymer nanocomposite so as to engineer materials with target mechanical or optical properties. One can tailor the inter-particle interactions and precisely control the assembly of the particles in the polymer matrix by functionalizing nanoparticle surfaces with polymers, and systematically tuning the composition, chemistry, molecular weight and grafting density of these grafted polymers. We have developed an integrated self-consistent approach involving Polymer Reference Interaction Site Model (PRISM) theory and molecular simulations to study polymer grafted nanoparticles in polymer matrix, and understand the effect of heterogeneity, such as monomer chemistry, monomer sequence, and polydispersity, in the polymer functionalization on the effective interactions, and dispersion/assembly of functionalized nanoparticles in a polymer matrix.

In the second part of my talk I will present our molecular simulation studies aimed at designing polycations for DNA delivery.   DNA delivery involves successful transfection of therapeutic DNA by a vector into target cells and expression of that genetic material. Viral vectors, while effective, can elicit harmful immunogenic responses, thus motivating ongoing research on non-viral transfection agents. Cationic polymers or polycations are a promising class of non-viral vectors due to their low immugenic responses and low toxicity, and their ability to bind to the polyanionic DNA backbone to form a polycation-DNA complex (polyplex) that is then internalized in the target cell. Combinatorial approaches have generated many polycations with differing DNA transfection efficacies, but there is a need for general design guidelines that can relate the molecular features of the polycation to its DNA transfection efficiency. Using atomistic and coarse-grained molecular dynamics simulations of DNA and polycations composed of polypeptides, we connect the thermodynamics of polycation-DNA binding and structure of the polycation-DNA complexes, both of which impact transfection efficiency, to polycation chemistry and architecture.

Previous Lecturers in the Series

2015

M. Scott Shell

University of California, Santa Barbara

2014

Ryan C. Hayward

University of Massachusetts, Amherst

2013 Hang Lu

Georgia Institute of Technology

2012 Todd Squires

University of California, Santa Barbara

2011

Yi Tang

University of California, Los Angeles

2010

Bartosz Grzybowski

Northwestern University

2009

Thomas M. Truskett

University of Texas at Austin