Microtechnologies for High-throughput High-content Developmental Biology and Neurogenetics
Series: Saville Lectures
Location: Friend Center Convocation Room
Date/Time: Wednesday, March 27, 2013, 4:00 p.m. - 5:00 p.m.
Professor Lu's lab is interested in engineering micro systems to address questions in systems neuroscience, developmental biology, and cell biology that are difficult to answer with conventional techniques. Micro technologies provide the appropriate length scale for investigating molecules, cells, and small organisms; moreover, one can also take advantage of unique phenomena associated with small-scale flow and field effects, as well as unprecedented parallelization and automation to gather quantitative and large-scale data about complex biological systems. She will show microfluidic systems coupled with artificial intelligence for automated high-resolution imaging and high-throughput genetic screens in C. elegans, and chips for imaging embryos and cells for developmental and functional studies. She will show micro systems for optogenetic experiments to dissect the function of neural circuits and behavioral output. Our methods enable such systems level studies 100-1000 times faster than traditionally done, and in many occasions yield unique quantitative data that cannot be obtained otherwise.