Assembly Line Antibiotic Biosynthesis
Series: Wilhelm Lectures
Location: Friend Center Convocation Room
Date/Time: Wednesday, September 18, 2013, 4:00 p.m. - 5:00 p.m.
Assembly lines have been a powerful engineering paradigm on account of their modularity. Many complex natural products, such as polyketide antibiotics, are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture has opened the door to the engineering of new antibiotics by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier in catalytic reaction engineering.