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Spatiotemporal Regulation of Signal Transduction in Living Cells

Speaker: Jin Zhang, Johns Hopkins University
Series: CBE Departmental Seminars
Location: Elgin Room (E-Quad A224)
Date/Time: Wednesday, February 26, 2014, 4:00 p.m. - 5:00 p.m.

The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. I will present studies where we combined genetically encoded fluorescent biosensors, targeted biochemical perturbations, mathematic modeling and superresolution imaging to probe the spatiotemporal regulation of signaling molecules such as cAMP, Protein Kinase A, calcineurin and Protein Kinase B.