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Personalized Therapeutics

Speaker: Debra Auguste, The City College of New York
Series: CBE Departmental Seminars
Location: Elgin Room (E-Quad A224)
Date/Time: Wednesday, April 23, 2014, 4:00 p.m. - 5:00 p.m.

Metastatic breast cancers (MBCs) have high mortality owing to aggressive proliferation and metastasis and a lack of diversified treatment options. Epidemiological studies support differences in MBC behavior by age, ethnicity, and BRCA1 gene status.  Our quantitative investigation of cell membrane surface chemistry in cell lines and human tissues has led to the design of a series of personalized therapeutics. Additionally, we focus on intervention in multiple pathways to simultaneously reduce metastasis and proliferation. Our synergistic approach - coupling cell chemistry and cell behavior - may transform how we think and design therapeutics. In addition to our efforts in drug delivery, we will show how responsive materials may be designed to regenerate tissue. Our in vitro, in vivo, and in silico results demonstrate that bioresponsive materials can induce a pro-healing response.