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Towards a Physical Chemistry of Bacterial Cells

Speaker: Ken Dill, Stony Brook University
Series: CBE Departmental Seminars
Location: Elgin Room (E-Quad A224)
Date/Time: Wednesday, October 25, 2017, 4:00 p.m. - 5:00 p.m.

Much of biology is explained by proteins doing their “day jobs”. But, some cell behaviors appear to arise from a different property of proteins —namely their folding and aggregation homeostasis (called proteostasis). We find that simple models of proteostasis can explain how cell growth rates depend on temperature, salts, and oxidative damage. Related modeling shows how the cell’s chaperones — which are the front line of the cell’s response to stresses — make clever protein folding and sorting decisions that are hardwired into physical chemical networks.