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Brynildsen Receives NSF CAREER Award

Mark Brynildsen, Assistant Professor of Chemical and Biological Engineering, has been awarded a Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF).  Brynildsen’s project, entitled “Metabolic Engineering to Potentiate Immunity and Discover Novel Antivirulence Therapies”, will focus on developing antivirulence therapies as a novel class of anti-infectives and an alternative to antibiotics, to which organisms have shown steadily increasing resistance.  In contrast to antibiotics, antivirulence therapies target host-pathogen interactions required for infection, and are consequently projected to be less prone to resistance development and less harmful to commensal (“good”) bacteria than are antibiotics.  A particular focus is on nitric oxide (NO), an antimicrobial naturally generated by immune cells.  The CAREER Program is an NSF-wide activity that offers the NSF’s most prestigious awards in support of junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research.