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Brynildsen Paper in Nature Biotechnology Points the Way to Lower Antibiotic Dosing

Recent research by a team at Boston University spearheaded by Mark Brynildsen, now Assistant Professor of Chemical and Biological Engineering at Princeton, has shown how bacteria can be forced to increase their production of reactive oxygen species (ROS)—either killing the bacteria outright, or making them vulnerable to antibiotics at lower dosages.  By developing genome-scale metabolic models describing the production of reactive oxygen species in the bacterium E. coli, and then perturbing this metabolic network, the team showed that they could increase the microbe’s susceptibility to killing by antibiotics. For more information, see the story on the Princeton University homepage, or for those with journal access, read the paper in Nature Biotechnology describing the work, “Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production”.