The size of a typical eukaryotic cell is usually of the order of ~10 μm. However, some cell types grow to very large sizes, up to 1 mm. Graduate student Marina Feric in the Brangwynne lab has used microrheology and quantitative imaging to show that large nuclei contain an elastic F-actin scaffold that mechanically stabilizes them against gravitational forces.
Clifford Brangwynne, Assistant Professor of Chemical and Biological Engineering, will receive the Howard B. Wentz, Jr. Junior Faculty Award from the School of Engineering and Applied Science (SEAS) at a SEAS-wide faculty meeting on May 28. The award of $40,000 in unrestricted research funds is “intended to recognize and assist promising junior faculty members”. Brangwynne’s research focuses on intracellular RNA/protein droplets: their assembly, biological func
Rodney D. Priestley and Clifford P. Brangwynne, both Assistant Professors of Chemical and Biological Engineering, have been named 2014 Sloan Fellows: Priestley in the field of Chemistry, Brangwynne in Computational & Evolutionary Molecular Biology. The Alfred P. Sloan Foundation established the Fellowships in 1955 to stimulate fundamental research by early-career scientists and scholars of outstanding promise. These two-year fellowships are awarded “in recognition of d
CBE doctoral student Marina Feric, and her advisor, CBE Assistant Professor Clifford P. Brangwynne, have discovered that gravity can play an important role in cells. Feric and Brangwynne set out to understand how liquid-like RNA/protein (RNP) organelles are stabilized within the nucleus of large frog cells. By using small probe particles to make micro-rheological measurements in the cell nucleus, they found that an actin biopolymer scaffold constrains the motion of RNP droplets. Unex
Clifford Brangwynne, Assistant Professor of Chemical and Biological Engineering, has been awarded a Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF). Brangwynne’s project, entitled “Non-Equilibrium RNA/Protein Liquids and Intracellular Phase Transitions”, will focus on elucidating two important aspects of RNA/protein liquids: 1) their assembly from soluble components, and 2) their material properties, which strongly impact their b
Clifford P. Brangwynne, Assistant Professor of Chemical and Biological Engineering, has just been named a Director’s New Innovator by the National Institutes of Health (NIH), in a press release issued today. The New Innovator award initiative, established in 2007, is designed specifically to support unusually creative new investigators with highly innovative research ideas who are within 10 years of their terminal degree, and is accompanied by a $1.5M research award. The NIH Di
Clifford P. Brangwynne, Assistant Professor of Chemical and Biological Engineering, was named a Searle Scholar for 2012 on April 13. Fifteen recently-appointed assistant professors in the chemical and biological sciences nationwide were selected for this honor from a pool of 186 researchers nominated by 125 institutions. The Searle Scholars Program will support Cliff's research on nucleolar function in cell growth control through a $300,000 grant over the next three years.
Clifford P. Brangwynne, Assistant Professor of Chemical and Biological Engineering, has received a three-year Program Research Grant from the Human Frontier Science Program (HFSP), on “RNA Helicases in RNA/Protein Body Assembly and Function: A Multi-scale Approach”. The grant will support studies of sub-cellular compartments which consist of assemblies of RNA and proteins, and how they carry out their biological functions. Brangwynne’s project team includes Ch
The November 25 issue of Science magazine contains a five-segment news focus section on “Mysteries of the Cell”, with each segment devoted to a particular unsolved mystery. One of the segments, entitled “How Does the Cell Position Its Proteins?”, contains excerpts from an interview with Clifford Brangwynne, Assistant Professor of Chemical and Biological Engineering, discussing his recent work: “this cytoplasmic fluid is actually highly structured, which
Mark P. Brynildsen and Clifford P. Brangwynne will join the Department of Chemical and Biological Engineering as Assistant Professors during the coming academic year. Each will expand and strengthen the department’s research portfolio in biological engineering. Brynildsen, who will start in September 2010 following a postdoctoral appointment in Biomedical Engineering at Boston University, specializes in host-pathogen interactions, bacterial persistence, and biofilms. Brangwynne, who will