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José Avalos

Selected Publications

  1. Avalos JL, Fink GR, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nature Biotechnol. 2013 Apr;31(4):335-41.
  2. Tao X, Avalos JL, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science. 2009 Dec; 18;326(5960):1668-74.
  3. Hoff, K., Avalos, JL., Sens, K. and Wolberger, C. Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure. 2006 Aug;14(8):1231-40.
  4. Cosgrove, MS., Bever, K., Avalos, JL., Muhammad, S., Zhang, X., Wolberger, C. The Structural Basis of Sirtuin Substrate Affinity. Biochemistry. 2006 Jun 20;45(24):7511-21.
  5. Avalos, JL., Bever, MK., Wolberger, C. Structure-Based Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme. Mol Cell. 2005 Mar 18;17(6):855-68. 6.
  6. Avalos, JL., Boeke, JD., and Wolberger, C. Structural Basis for the Mechanism and Regulation of Sir2 Enzymes. Mol. Cell. 2004; Mar;12(13): 639-648.
  7. Avalos, JL., Celic, I., Muhammad, S., Cosgrove, MS, Boeke, JD., and Wolberger, C. Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide. Mol. Cell. 2002; Sep;10(3): 523-535.
  8. Smith J.S., Avalos, JL., Celic, I., Muhammad, S., Wolberger, C., and Boeke, J.D. Sir2 family of NAD(+)-dependent protein deacetylases. Methods Enzymol, 2002; 353: 282-300.
  9. Sauve, AA., Celic, I., Avalos, JL., Deng, H., Boeke, JD., and Schramm, VL. Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochemistry, 2001 Dec 25; 40(51): 15456-15463.
  10. Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD. A phylogenetically conserved NAD+- dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63