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Mapping local and global liquid-liquid phase behavior in living cells using light-activated multivalent seeds
bioRxiv, 2018
Bracha D, Walls MT, Wei M-T, Zhu L, Kurian M, Toettcher JE, Brangwynne CP*

Protein phase separation provides long term memory of transient spatial stimuli
bioRxiv, 2018
Dine E, Gil AA, Uribe G, Brangwynne CP, Toettcher JE*

Physical principles of intracellular organization via active and passive phase transitions
Reports on Progress in Physics, 2018 [PDF]
Berry J, Brangwynne CP*, Haataja M*

Liquid phase condensation in cell physiology and disease
Science, 2017 [PDF
Shin Y, Brangwynne CP*

Phase behavior of disordered proteins underlying low density and high permeability of liquid organelles
Nature Chemistry, 2017 [PDF] [PrincetonU Homepage]
Wei M-T, Elbaum-Garfinkle S, Holehouse A, Chen CC-H, Feric M, Arnold CB, Priestley RD, Pappu RV*, Brangwynne CP*

RNA puts a freeze on cells
Nature, 2017 [PDF]
Sanders DW*, Brangwynne CP*

Microfluidic immobilization and subcellular imaging of developing Caenorhabditis elegans
BioRXiv 2017 [link]
Shivers J, Uppaluri S, Brangwynne CP*


Farming and public goods production in C.elegans populations
Proceedings of the National Academy of Sciences USA2017 [PDF] [PrincetonU Homepage]
Thutupalli S*, Uppaluri S*, Constable GWA, Levin SA, Stone HA, Tarnita CE , Brangwynne CP*

Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets
Cell2017 [PDF] [PrincetonU Homepage] [Alzforum] [Preview: Shining a Light on Phase Separation]
Shin Y, Berry J, Pannucci N, Haataja M, Toettcher JE*, Brangwynne CP*

Biophysical characterization of organelle-based RNA/protein liquid phases using microfluidics
Soft Matter2016 [PDF]
Taylor N, Elbaum-Garfinkle S, Vaidya N, Zhang H, Stone HA, Brangwynne CP*

Hierarchical size scaling during multicellular growth and development
Cell Reports2016 [PDF] [F1000]
Uppaluri S, Weber SC, Brangwynne CP*

Cell division: A sticky problem for chromosomes
Nature, 2016 [PDF]
Brangwynne CP*, Marko JF*

Coexisting liquid phases underlie nucleolar subcompartments
Cell, 2016 [PDF][AudioInterview] [PrincetonU Homepage]
Feric M§, Vaidya N§, Harmon TS, Mitrea DM, Zhu L, Richardson TM, Kriwacki RW, Pappu RV, Brangwynne CP*

Liquids, fibers and gels: The many phases of neurodegeneration
Developmental Cell, 2015 [PDF]
Elbaum-Garfinkle S, Brangwynne CP*

Soft viscoelastic properties of nuclear actin age oocytes due to gravitational creep
Scientific Reports, 2015 [PDF]
Feric M, Broedersz C, Brangwynne CP*

Polymer physics of intracellular phase transitions
Nature Physics, 2015 [PDF]
Brangwynne CP*, Tompa P, Pappu RV

Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion
Proceedings of the National Academy of Sciences USA, 2015 [PDF]
Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW

RNA controls polyQ protein phase transitions
Molecular Cell, 2015 [PDF] [Preview: Raining Liquids]
Zhang H, Elbaum-Garfinkle S, Langdon E, Taylor N, Occhipinti P, Bridges A, Brangwynne CP*, Gladfelter, AS*

RNA transcription modulates phase transition-driven nuclear body assembly
Proceedings of the National Academy of Sciences USA, 2015 [PDF]
Berry JM, Weber SC, Vaidya N, Haataja M*, Brangwynne CP*

A size threshold governs Caenorhabditis elegans developmental progression
Proceedings of the Royal Society B, 2015 [PDF]
Uppaluri S, Brangwynne CP*

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
Proceedings of the National Academy of Sciences USA, 2015 [PDF] [F1000]
Elbaum-Garfinkle S, Kim Y, Szczepaniak C, Eckmann C, Myong S, Brangwynne CP*

Nuclear Bodies: the emerging biophysics of nucleoplasmic phases
Current Opinion in Cell Biology, 2015 [PDF]
Zhu L, Brangwynne CP*

Worms under pressure: bulk mechanical properties of C.elegans are independent of the cuticle
Biophysical Journal, 2015 [PDF]
Gilpin W, Uppaluri S, Brangwynne CP*

Inverse size scaling of the nucleolus by a concentration dependent phase transition
Current Biology, 2015 [PDF] [F1000]
Weber SC, Brangwynne CP*

Phase transitions and size scaling of membrane-less organelles
Journal of Cell Biology, 2013 [PDF]
Brangwynne CP*

Spatial organization of the cell cytoplasm by position dependent phase separation
Physical Review Letters, 2013 [PDF]
Lee C-F, Brangwynne CP, Gharakhani J, Hyman AA, Julicher F

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells
Nature Cell Biology, 2013
[PDF] [C & EN Article] [The Atlantic] [The Scientist] [PrincetonU Homepage] [Dartmouth]
Feric M, Brangwynne CP* 

Nuclear Mechanics: Lamin webs and pathological blebs
Nucleus, 2013 [PDF]
Broedersz CP, Brangwynne CP*

The Micro and Macro of RNA Function
Molecular Biology of the Cell, 2013 [PDF]
Brangwynne CP*, Johnson TL*

In Retrospect: The Origin of Life
Nature, 2012 [PDF] ["News" Coverage]
Hyman AA*, Brangwynne CP*

Attenuated short wavelength buckling and force propagation in a biopolymer-reinforced rod
Soft Matter, 2012 [PDF]
Shan WL, Chen Z, Broedersz CP, Gumaste AA, Soboyejo W, Brangwynne CP*

Getting RNA and Protein in Phase
Cell, 2012 [PDF] [Press]
Weber SC, Brangwynne CP*

Beyond stereo-specificity: liquids and mesoscale organization of cytoplasm
Developmental Cell, 2011 [PDF]
Hyman AA*, Brangwynne CP*

Active Liquid-like Behavior of Nucleoli Determines their Size and Shape in Xenopus laevis Oocytes
Proceedings of the National Academy of Sciences USA, 2011 [PDF] [Current Biology Dispatch] [Nucleus Commentary] [F1000]
Brangwynne CP*, Mitchison TJ, Hyman AA

Soft active aggregates: mechanics, dynamics, and self-assembly of liquid-like intracellular protein bodies
Soft Matter, 2011 [PDF]
Brangwynne CP*

* = Corresponding author


Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos
Current Biology, 2010 [PDF] [F1000]
Greenan G, Brangwynne CP, Jaensch S, Gharakhani J, Jülicher F, Hyman AA

Germline P granules are liquid droplets that localize by controlled dissolution/condensation
Science 2009 [PDF] [F1000]
Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Jülicher F, Hyman AA

Intracellular Transport by Active Diffusion
Trends in Cell Biology, 2009 [PDF]
Brangwynne CP, Koenderink GH, MacKintosh FC, Weitz DA

Mechanical response of cytoskeletal networks
Methods in Cell Biology, Vol. 89 Ch. 19, 2008 [PDF]
Gardel ML, Kasza KE, Brangwynne CP, Liu J, Weitz DA

Cytoplasmic diffusion: molecular motors mix it up
Journal of Cell Biology, 2008 [PDF]
Brangwynne CP, Koenderink GH, MacKintosh FC, Weitz DA

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly
Journal of Cell Science, 2008 [PDF]
Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ

Nonequilibrium microtubule fluctuations in a model cytoskeleton
Physical Review Letters, 2008 [PDF]
Brangwynne CP, Koenderink GH, MacKintosh FC, Weitz DA

Force fluctuations and polymerization dynamics of intracellular microtubules
Proceedings of the National Academy of Sciences USA, 2007 [PDF] [F1000]
Brangwynne CP, MacKintosh FC, Weitz DA

The cell as a material
Current Opinion in Cell Biology, 2007 [PDF]
Kasza KE, Rowat AC, Angelini TE, Liu J, Brangwynne CP, Koenderink GH, Weitz DA

Bending dynamics of fluctuating biopolymers probed by automated high-resolution filament tracking
Biophysical Journal, 2007 [PDF]
Brangwynne CP, Koenderink GH, Barry E, Dogic Z, MacKintosh FC, Weitz DA

A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels
FASEB Journal, 2007 [PDF]
Leung LY, Tian D, Brangwynne CP, Weitz DA, Tschumperlin DJ

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement
Journal of Cell Biology, 2006 [PDF] [Current Biology Dispatch] [F1000]
Brangwynne CP, MacKintosh FC, Kumar S, Geisse NA, Talbot J, Mahadevan L, Parker KK, Ingber DE, Weitz DA

Glioma Expansion in Collagen I Matrices: Analyzing Collagen Concentration-Dependent Growth and Motility Patterns
Biophysical Journal, 2005 [PDF]
Kaufman LJ, Brangwynne CP, Kasza KE, Filippidi E, Gordon VD, Deisboeck TS, Weitz DA

Symmetry-Breaking in Mammalian Cell Cohort Migration During Tissue Pattern Formation: Role of Random-Walk Persistence
Cell Motility and the Cytoskeleton, 2005 [PDF]
Huang S§, Brangwynne CP§, Parker KK, Ingber DE

Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces
FASEB Journal, 2002 [PDF]
Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse N, Whitesides GM, Ingber DE

Symmetry breaking in cultured mammalian cells
In Vitro Cell & Developmental Biology, 2000 [PDF]
Brangwynne C, Huang S, Parker KK, Ingber DE

Pictures in cell biology: squaring up to the cell shape debate
Trends in Cell Biology, 1999 [PDF]
Chen CS, Brangwynne C, Ingber DE

§ = Equal contribution