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A Nuclear F-actin Scaffold Stabilizes RNP Droplets Against Gravity in Large Cells

The size of a typical eukaryotic cell is usually of the order of ~10 μm. However, some cell types grow to very large sizes, up to 1 mm. Graduate student Marina Feric in the Brangwynne lab has used microrheology and quantitative imaging to show that large nuclei contain an elastic F-actin scaffold;that mechanically stabilizes them against gravitational forces, which become increasingly important in larger cells.

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For more infomation about Professor Brangwynne's research please see the Soft Living Matter Group site.