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Incorporation of Unnatural Amino Acids into Lasso Peptides

Professor Jamie Link and grad student Frank Piscotta, in collaboration with the Liu group at Texas A&M, have provided the first demonstration that unnatural amino acids can be introduced into the antimicrobial lasso peptide microcin J25.  Four different amino acids were tolerated at four different positions, and all 16 of these variants retained antimicrobial activity. 

See more at http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/c4cc07778d#!divAbstract.

For more infomation about Professor Link's research please see The Link Lab site.