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Self-Assembly of Catenanes from Lasso Peptides

[3]catenaneCatenanes are interlocked molecules in which constituents are held together by mechanical bonds rather than covalent bonds.  Jamie Link and former grad student Caitlin Allen *16 built a catenane with 3 interlocking rings (a [3]catenane) by enzymatically cleaving a variant of the lasso peptide microcin J25.  The cleaved peptides self-assembled into the [3]catenane shown here, the structure of which was determined by NMR. 

Read more about it here: http://pubs.acs.org/doi/abs/10.1021/jacs.6b09454.

For more infomation about Professor Link's research please see The Link Lab site.