Skip over navigation

Self-Assembly of Catenanes from Lasso Peptides

[3]catenaneCatenanes are interlocked molecules in which constituents are held together by mechanical bonds rather than covalent bonds.  Jamie Link and former grad student Caitlin Allen *16 built a catenane with 3 interlocking rings (a [3]catenane) by enzymatically cleaving a variant of the lasso peptide microcin J25.  The cleaved peptides self-assembled into the [3]catenane shown here, the structure of which was determined by NMR. 

Read more about it here:

For more infomation about Professor Link's research please see The Link Lab site.