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Erik J. Sorensen

Research Focus


Organic chemistry, chemical synthesis of bioactive natural products and molecular probes for biological research, bioinspired strategies for chemical synthesis, architectural self-constructions, novel methods for synthesis.

Selected Recent Publications

  • “Synthesis Enables a Structural Revision of the Mycobacterium Tuberculosis-produced Diterpene, Edaxadiene”, J. E. Spangler, C. A. Carson and E. J. Sorensen, Chem. Sci., 2010, 1, 202-205.
     
  • “Seebach’s Conjunctive Reagent Enables Double Cyclizations”, B. D. Chandler, J. T. Roland, Y. Li and E. J. Sorensen, Org. Lett., 2010, 12, 2746-2749.
     
  • “A Hypervalent Iodine-Induced Double Annulation Enables a Concise Synthesis of the Pentacyclic Core Structure of the Cortistatins”, J. L. Frie, C. S. Jeffrey, and E. J. Sorensen, Org. Lett., 2009, 11, 5394-5397.
     
  • “Bond formations by intermolecular and intramolecular trappings of acylketenes and their applications in natural product synthesis”, K. P. Reber, S. D. Tilley and E. J. Sorensen, Chem. Sci. Rev., 2009, 38, 3022-3034.
     
  • "A Nature-Inspired Diels-Alder Reaction Facilitates Construction of the Bicyclo[2.2.2]octane Core of Andibenin B", J. E. Spangler, E. J. Sorensen, Tetrahedron, 2009, 65, 6739-6745.
     
  • "A Rapid, Asymmetric Synthesis of the Decahydrofluorene Core of the Hirsutellones", S. D. Tilley, K. P. Reber and E. J. Sorensen, Org. Lett. 2009, 11, 701-703.
     
  • "An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles", J. S. Schneekloth, Jr., J. Kim and E. J. Sorensen, Tetrahedron. 2009, 65, 3096–3101.
     
  • "A synthesis of the tricyclic core structure of FR901483 featuring an Ugi four-component coupling and a remarkably selective elimination reaction", H. Seike, E. J. Sorensen, Synlett. 2008, 5, 695-701.
     
  • "Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxidates", M. J. Evans, G. M. Morris, J. Wu, A. J. Olson, E.J. Sorensen, B. F. Cravatt, Mol. Biosyst. 2007, 3, 495-506.
     
  • "Classical carbonyl reactivity enables a short synthesis of the core structure of acutumine", R. J. Moreau, E. J. Sorensen, Tetrahedron. 2007, 63, 6446-6453.
     

Erik J. Sorensen

Sorensen Lab Webpage
ejs@princeton.edu
Frick Laboratory, 132
Phone: 609-258-8135

Faculty Assistant:
Denise D'Auria
denised@princeton.edu
Frick Laboratory, 228
Phone: 609-258-5202