Seminar (organic): Patrick J. Guiry, University College Dublin
<p>Patrick J. Guiry<br />Centre for Synthesis and Chemical Biology<br />School of Chemistry and Chemical Biology<br />University College Dublin</p>
<p><strong>Recent Results in Total Synthesis and Asymmetric Catalysis From Dublin</strong></p>
<p>Asymmetric catalysis, one approach for the preparation of enantiomerically pure compounds and the focus of research in both academic and industrial laboratories, is an attractive technology as a small amount of enantiomerically pure material can produce large quantities of enantiomerically enriched or enantiopure material. Research in asymmetric catalysis todate highlights the difficulty in finding a 'universal' ligand suitable for a wide spectrum of reactions and substrates. For this reason the preparation and testing of new ligands for asymmetric catalysis is an active research field.</p>
<p>This presentation will describe the synthesis of C2- and non-C2-symmetric analogues of our bis-oxazoline ligands <strong>1</strong> and their application in the Nozaki-Hiyama-Kishi allylation, crotylation, methallylation and homoallenylation of aldehydes. In addition, the products of homoallenylation (β-allenols) will be tested as substrates for a series of reactions in order to study their usefulness in synthetic chemistry.</p>
<p>The synthesis and biological evaluation of Lipoxin A4 analogue <strong>2</strong>, and the subsequent development of synthetic methodology applied to the asymmetric synthesis of natural products, e.g. pheromone <strong>3</strong> and (-)-frontalin <strong>4</strong>, will also be discussed.</p>
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Frick Chemistry Laboratory, Taylor Auditorium  ·  3:00 p.m.– 4:30 p.m.