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November 28, 2012   >>
Wednesday, November 28
11/28 - Seminar (organic): Young Ho Rhee, Pohang University of Science and Technology
<p>Young Ho Rhee - <a href="" target="_blank">speaker's webpage</a><br />Department of Chemistry<br />Pohang University of Science and Technology<br />Host: Martin Semmelhack</p>
<p><strong>Developing new diversity-generating synthetic strategies based on metal catalysis</strong></p>
<p>The diversity of natural products has attracted synthetic chemists over the past decades. Thus, developing new methodologies that can introduce molecular diversity with high chemical efficiency represents a primary goal in synthetic organic chemistry. Due to their high reactivity and chemoselectivity, organometal catalysts may play a unique role. In this presentation, our achievements in this area will be briefly introduced.  First part of the talk will focus on developing structural diversity-generating strategies using Au-catalyzed reactions of 3-alkoxy-1,6-enynes.<sup>1,2</sup>  The second part of talk will reveal our recent results on the synthesis of Pd-catalyzed synthesis of stereodefined N,O-acetals and their utilities as key elements in developing stereodiversity-generating<sup>3,4</sup> and substituent diversity-generating strategies.<sup>5</sup> Mechanistic aspects of the catalytic reactions as well as potential synthetic applications will be also discussed.</p>
References<br />1. <em>Angew. Chem. Int. Ed</em>. <strong>2008</strong>, 47, 2263.<br />2. <em>Org. Lett</em>. <strong>2008</strong>, 10, 2605.<br />3. <em>J. Am. Chem. Soc</em>. <strong>2009</strong>, 131, 14660.<br />4. <em>J. Am. Chem. Soc</em>. <strong>2012</strong>, 134, 4011.<br />5. <em>Angew. Chem. Int. Ed</em>. <strong>2012</strong>, in press.</p>
Frick Chemistry Laboratory, Taylor Auditorium  ·  4:30 p.m. 6:00 p.m.