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<<  February 26, 2013   >>
Tuesday, February 26
2/26 - BMS Symposium in Organic Synthesis: Huw Davies, Emory University & Percy Carter, Bristol-Myers Squibb Company
<p><strong>Bristol-Myers Squibb Mini Symposium in Organic Synthesis</strong></p>
<p><strong>2:00 p.m.</strong><br />Introductory Remarks</p>
<p><strong>2:05 p.m.</strong><br />
  Christopher Prier<br />Bristol-Myers Squibb Fellow<br />Princeton University</p>
<p><strong>The Photoredox α-Arylation of Amines: Discovery, Scope, and Mechanism</strong></p>
<p><strong>2:30 p.m.</strong><br />Thomas J. Graham<br />Bristol-Myers Squibb Fellow<br />Princeton University</p>
<p><strong>Enatioselective Labeling of Organic Molecules with Fluorine-18</strong></p>
<p><strong>3:00 p.m.</strong><br />Percy Carter, Executive Director<br />Immunology Chemistry<br />Bristol-Myers Squibb</p>
<p><strong>Discovery of an antagonist of CC Chemokine Receptor 2 suitable for clinical development</strong></p>
<p>We describe the development of the structure-activity relationships in a series of lactam-conjugated tri-substituted cyclohexanes as CCR2 antagonists.  This work culminated in the discovery of BMS-741672 as a potent, selective, and orally bioavailable CCR2 antagonist that was moved into clinical development.</p>
<p><strong>3:50 p.m.</strong><br />Coffee Break</p>
<p><strong>4:15 p.m.</strong><br />Featured speaker: Huw Davies - <a href="http://chemistry.emory.edu/faculty/davies/" target="_blank">speaker's webpage</a><br />Department of Chemistry<br />Emory University<br />Host: Abby Doyle</p>
<p><strong>Challenging the Scope of Carbenoid-Induced C-H Functionalization</strong></p>
<p>The metal-catalyzed reactions of diazo compounds have broad utility in organic synthesis. Donor/acceptor carbenoids are capable of highly enantioselective intermolecular C-H functionalization of hydrocarbons. The donor/acceptor carbenoids are highly reactive but are much more selective than conventional carbenoids lacking the donor group.  Highly regio- and stereoselective C-H functionalization of a variety of substrates can be conducted without the requirement of a directing group to control the site of functionalization. Furthermore the transformation can be used as a surrogate of many of the classic reactions of organic synthesis, such as the aldol reaction, Mannich reaction, Michael addition and the Claisen rearrangement. An exciting new development is the combined C-H functionalization/Cope rearrangement (CHCR), which generates products containing two new stereocenters with excellent control of relative and absolute configuration. This presentation will illustrate the scope of carbenoid-induced C-H functionalization and illustrate the collaborative research currently ongoing at the NSF Center for Selective C-H Functionalization.</p>
<p><strong>5:15 p.m.</strong><br />Reception, Taylor Commons</p>
Frick Chemistry Laboratory, Taylor Auditorium  ·  2:00 p.m. 5:15 p.m.