5/7 - Seminar (organic): Sarah Reisman, Caltech
Sarah Reisman - speaker's webpage
Division of Chemistry and Chemical Engineering
California Institute of Technology
Host: Abby Doyle
New Methods and Strategies for the Synthesis of Polycyclic Natural Products
The overarching goal of the Reisman laboratory is to discover, develop, and study new chemical reactions within the context of natural product total synthesis. The chemical synthesis of natural products enables the study of their biological properties, and can provide access to synthetic derivatives with improved therapeutic properties or that can serve as mechanistic probes. As importantly, these synthetic undertakings serve to drive innovation in, and deepen our fundamental understanding of, organic and organometallic chemistry. Our laboratory has ongoing research programs targeting the chemical syntheses of members of the epidithiodiketopiperazines natural products. The densely packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current synthetic methodology. This seminar will describe our latest progress in both our methodological and target-directed synthesis endeavors.