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NOV 12 | Anthony Long, UC Irvine

TITLE: "Alternatives to Association Mapping for the Dissection of Complex Traits"

Audience: HOST: David L. Stern

Location: 10 Guyot Hall

Date/Time: 11/12/09 at 12:30 pm - 11/12/09 at 1:30 pm

In the nineties it was widely believed that many Quantitative Trait Loci (QTL) could be positionally cloned in much that same manner as Medelian disease loci.  Things did not really pan out.  Early in this decade it was widely believed that Genome-wide Association Studies (GWAs) would save the day.  Now that several human GWAs are complete there is much less certainty.  Typical high powered studies are only able to account for a small percentage of standing genetic variation.  What to do next?  A new approach gaining ground employs "synthetic" populations to dissect complex traits.  We are behind one such synthetic population resource in Drosophila.  We will discuss some of the features of such populations, and why we think they may give us some leverage other methods have lacked.


Anthony Long's website: http://www.faculty.uci.edu/profile.cfm?faculty_id=4563

Category: EEB 522 Colloquium

Department: EEB