Princeton University

I am an evolutionary ecologist with strong interests in the processes that drive heterogeneity in hosts, parasites, and diseases.  I'm particularly keen to understand the role of immune systems in brokering host-parasite interactions, generating substantial self-harm (or immunopathology), and altering transmission dynamics of parasites.  Recent projects in the Graham Group have focused on the following questions:

• Why do sheep vary so much in antibody responsiveness?
• What are the consequences of immunopathology for transmission of malaria parasites?
• Which cytokines primarily drive a cytokine storm?
• What are the relative roles of resource limitation and immunological killing in within-host control of parasite populations?
• Why do adaptive immune responses cross-react?