- Ecology and Evolutionary Biology
- Lewis-Sigler Institute for Integrative Genomics
My research combines both computational and experimental approaches to address a broad range of topics in Evolutionary Genetics/Genomics including: (1) Quantifying the mode and strength of selection acting on coding and non-coding DNA in the Drosophila genome; (2) Quantifying the impact of changes in population size and and structure on patterns of genome variability in D. melanogaster and its close relatives; (3) Understanding the nature of species boundaries in several Drosophila and Lepidopteran species; and (4) Quantifying recombination rate variation in the genome and its effects on patterns of genome variability and evolution.
1. Andolfatto, P. 2008. Controlling type-I error of the McDonald-Kreitman test in genome wide scans for selection on noncoding DNA. Genetics, 180:1767-71.
2. Haddrill, P.R., D. Bachtrog and P. Andolfatto. 2008. Positive and negative selection on noncoding DNA in Drosophila simulans. MBE, 25:1825-1834.
3. Jensen, J. D., K. R. Thornton, and P. Andolfatto, 2008. An approximate Bayesian estimator suggests strong recurrent selective sweeps in Drosophila, PLoS Genetics, 4:e1000198.
4. Jeong, S., M. Rebeiz, Andolfatto, P., T. Werner, J. True and S. B. Carroll. 2008. The evolution of gene regulation underlies the morphological divergence of two closely related Drosophila species, Cell, 132:783-793.
5. Andolfatto, P., 2007 Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome, Genome Research, 17:1755-62.