Advanced Scaffold Based Approaches for Tissue Engineering
Speaker: Antonios Mikos, Rice University
Department: Chemical & Biological Engineering
Location: Engineering Quadrangle A224
Date/Time: Wednesday, October 9, 2013, 4:00 p.m. - 5:00 p.m.
Scaffold based approaches for tissue regeneration range from the development of innovative biomaterials that can be tailored with appropriate mechanical and biological signals to regenerate tissue in specific sites in the body to applying implants comprising existing biomaterials approved for use in certain clinical applications in strategies to encourage tissue regeneration. For example, our laboratory has developed a variety of biodegradable polymeric scaffolds for the controlled delivery of biologically active agents and/or progenitor stem cell populations to promote regeneration of tissues such as bone and cartilage. Further, our laboratory has explored the application of bioreactor culture of progenitor cell populations on fiber mesh scaffolds to produce extracellular matrix constructs containing biologically active signals to direct cellular differentiation and tissue formation. This talk will present recent examples from our laboratory to illustrate designer scaffold-based approaches for tissue engineering, as well as examples of emerging applications of clinically available biomaterials as components of implant-based strategies to promote tissue regeneration.