Swathi Arur, MD Anderson Cancer Center, ERK substrate networks in Development and Disease
Work in the Arur Lab utilizes the nematode Caenorahbditis elegans and germ line development to study ERK signaling. A long-term goal of the lab is to understand how active ERK2 controls and co-ordinates multiple different developmental events in one tissue. We find that downstream to ERK2 the linear RAS-ERK pathway becomes an intricate network of signaling molecules, with at least 30 direct effectors, each of which functions in its own signaling module to govern an ERK dependent event. We also find extensive signal-integration and cross-talk of ERK with other signaling pathways such as the wnt signaling pathway, the chromatin modification machinery, the miRNA processing cascade. Unraveling in a systematic way, how each ERK substrate regulates different biological processes during normal development will a) uncover novel functions of each substrate protein in a specific biological process and b) also allow us to understand the role of phosphorylation on each substrate in both developmental disorders and oncogenesis, where likely the downstream ERK substrates are key drivers of the disease.
Location: Carl Icahn Lab 101
Date/Time: 11/18/13 at 4:15 pm - 11/18/13 at 5:15 pm
Category: Quantitative & Computational Biology
Department: Lewis-Sigler Institute