The Kruglyak Lab conducts experiments in model organisms, as well as computational analyses, aimed at understanding how changes at the level of DNA are shaped by molecular and evolutionary forces, and how these changes lead to all the observable differences among individuals within a species.
News
Graduate Student Noorossadat Torabi's research is featured on GenomeWeb in connection to a paper she co-authored with Leonid Kruglyak in the July issue of PLoS Genetics.
Image from Kruglyak lab featured on PLoS Biology cover
A figure (right) created by former lab member Hannah Seidel is the featured image for the July 2011 issue of PLoS Biology. Dr. Seidel, now at the University of Wisconsin, took the photo while in the Kruglyak lab, and it accompanies her paper, "A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans." The paper is also covered in a PLoS Biology Primer, "Invertebrate post-segregation distorters: A new embryo-killing gene."
The article has also has been selected and evaluated by the Faculty of 1000 (F1000), which places the work in their library of the top 2% of published articles in biology and medicine.
The photo caption is: Embryos on the left and right have arrested at the 2-fold stage of embryogenesis due to developmental defects caused by the sperm-delivered toxin, PEEL-1. The hatched larvae in the center of the image has developed normally because this animal has inherited a single copy of the antidote gene, zeel-1.
The photo caption is: Embryos on the left and right have arrested at the 2-fold stage of embryogenesis due to developmental defects caused by the sperm-delivered toxin, PEEL-1. The hatched larvae in the center of the image has developed normally because this animal has inherited a single copy of the antidote gene, zeel-1.
Of Note:
From Bubbles, Bread, and Beer in the June 22, 2010 New York Times Opinionator- "Studying yeast genes gives us a window into what some of our most essential genes are doing."
