The Kruglyak Lab conducts experiments in model organisms, as well as computational analyses, aimed at understanding how changes at the level of DNA are shaped by molecular and evolutionary forces, and how these changes lead to all the observable differences among individuals within a species.
May 23, 2013 - Post-doctoral student Alejandro Burga Ramos was recently awarded a Jane Coffins Child Foundation Post-doctoral Fellowship.
February 22, 2013 - Finding the sources of missing heritability in a yeast cross.
A new study recently released in the journal Nature, with Kruglyak lab graduate student Joshua Bloom as lead author, is gaining national attention and is a featured story on the University website.
Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the "missing heritability" problem.
Bloom's research in yeast suggests that missing heritability may not be missing after all, and that heritability in humans may be hidden due only to the limitations of modern research tools. The research has implications for the design of future studies aimed at unraveling heritable variation in humans and other species.
Commentary on The Molecular Ecologist.
Featured at http://www.nigms.nih.gov/