The McClean Lab has moved to the University of Wisconsin-Madison!
The McClean Lab recently moved to the Department of Biomedical Engineering at the University of Wisconsin-Madison. A new webpage will be up at Wisconsin soon! You can check out Megan's new faculty profile . In the meantime, information on this website regarding research interests and publications remains largely correct
The McClean Lab studies and engineers signal processing in biological networks
Cells must sense and process diverse stimuli in order to survive and thrive. Our research focuses on experimentally and theoretically answering the following questions about biological signal processing:
Signaling Specificity: How do signaling pathways that share multiple components or regulatory interactions respond specifically to their input without crosstalk? Under what conditions is crosstalk desirable or functional?
Determination of in vivo kinetics: How fast does a signal propagate through a signaling pathway? How does this determine the bandwidth, or information carrying capacity, of the pathway? How does this signaling speed set appropriate thresholds and filtering behavior?
Transcription factor regulation: How are transcription factors regulated to produce appropriate transcriptional outputs? How can the dynamics of transcription factor activity be used to differentially regulate transcriptional targets? What is the transfer function between transcription factor concentration and transcriptional output?
Controllability: Given our understanding of the basic principles of biological signal processing can we control and engineer biological networks for applications in biomedicine and bioengineering?
Upcoming Seminars and Presentations:
- December 5, 2013: University of Chicago
- December 10, 2013: Integrated Science Shorts, Princeton University