Skip over navigation


Dexter, J., Kotopka, B., Xu, P., Liu, B., Botstein, D., and McClean, MN.(2015) Bandwidth measurements elucidate a rapid timescale for the regulation of aromatic amino acid metabolism in the budding yeast, Saccharomyces cerevisiae Physical Biology (In Review) Request Preprint

Dexter, J.P., Xu, P., Gunawardena, J., and McClean, MN.(2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae BMC Systems Biology 9:17

Melendez, J., Patel, M., Oakes, B.,Xu, P., Morton, P., and McClean, MN.(2014) Real-time optogenetic control of intracellular protein concentration in microbial cell cultures Integrative Biology 6(3) 366-72

Bisaria, A., Hersen, P., and McClean, MN.(2014) Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells Methods Mol Biol. 1205111-29

Caudy, AA. et al (2013) A new system for comparative functional genomics of Saccharomyces yeasts Genetics 195(1) 275-87

Petrenko, N. Chereji, RV., McClean, MN., Morosov, AV., Broach, JR. (2013) Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses Mol Biol Cell 24(12) 2045-57

Miermont, A., Waharte, F., Hu, S., McClean, MN., Bottani, S., Leon, S., and Hersen, P. (2013) Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding Proc Natl. Acad. Sci. USA 110(14) 5725-30

McIsaac RS, Silverman SJ, Parsons, L. Xu, P., Briehof, R. McClean MN, Botstein, D. (2013) Visualization and analysis of mRNA molecules using Fluorescence in situ hybridization in budding yeast J. Vis. Exp., Jun 14;(76) JOVE Video

McIsaac RS, Silverman SJ, McClean MN, Gibney PA, Macinskas J Hickman MJ Petti AA and Botstein D (2012) Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae Mol Biol Cell 22 (22) 4447-4459

McClean, MN, Hersen, P., Ramanathan, S., (2011) Measuring in vivo signaling kinetics in a mitogen-activated protein kinase pathway using dynamic input stimulation Methods in Molecular Biology 734 101-119

Miermont, A., Uhlendorf, J., McClean, M., and Hersen, P., (2011) The Dynamical Systems Properties of the HOG Signaling Cascade Journal of Signal Transduction 

McClean MN., Hersen P., Ramanathan S., (2009) In vivo measurement of signaling cascade dynamics. Cell Cycle 8 373-376

Hersen P*., McClean MN*., Mahadevan L., Ramanathan S., (2008) Signal Processing by the HOG MAP kinase pathway. Proc. Natl. Acad. Sci. USA 105 (20) 7165-7170

McClean, MN., Mody, A., Broach, J., and Ramanathan, S. (2007). Decision Making in MAP Kinase pathways. Nat. Genet. 39 (4) 409-414