Perlstein lab provides insight into antidepressants
4/24/12 - Research carried out in the laboratory of Lewis-Sigler Fellow Ethan Perlstein has shown a self-degradation response to the antidepressant Zoloft in yeast cells that could help provide new answers to lingering questions among scientists about how antidepressants work, as well as support the idea that depression is not solely linked to the neurotransmitter serotonin. This research was published online April 18 in PLoS ONE and was supported by the Lewis-Sigler Institute.
"Altogether, our work suggests that the serotonin-based theory might be an oversimplification and that the cause of depression is not a closed story," Perlstein says. "In my lab, future research will aim to integrate the multiple, interwoven strands that make up the totality of antidepressant pharmacology — including but also beyond serotonin — and translate this knowledge into better antidepressants and diagnostic tools for depression." (Read more at Princeton.edu, and at ScienceNews.org and BioWorld.)