David Rand, Warwick U, Design principles and dynamics in clocks, cell cycles and signals
I will review three recent pieces of work that bring out different aspects of System Biology research that I am involved in e.g. modelling, tools/algorithms for analysis of imaging, transcriptomics and other data, analytical tools & techniques for understanding design principles. I will discuss three topics. Firstly, coupling of the circadian clock and cell cycle in mammalian cells. Secondly, a radical revision of the Nrf2 signalling system. Stress responsive signalling coordinated by Nrf2 provides an adaptive response for protection against toxic insults, oxidative stress and metabolic dysfunction. Thirdly, the question of what lies behind temperature compensation of circadian clocks. Temperature compensation, one of the key themes of circadian biology, is about the constancy or near-constancy of the free-running period under changing temperature but it is not clear how evolution acts on the free-running period since in physiological conditions the clock is entrained to the day–night cycle and therefore has a constant period of 24 h. It therefore seems reasonable to hypothesise that temperature compensation for the free-running clock is a consequence of the selective pressure on some other aspect of the entrained circadian clock. I will use new experimental data and mathematical results to suggest a resolution this question.
Location: Joseph Henry Room, Jadwin Hall
Date/Time: 04/29/13 at 12:00 pm - 04/29/13 at 1:00 pm
Department: Lewis-Sigler Institute