Events - Daily
|Monday, October 01|
Rong Li, Stowers Institute, A numbers game: effects of chromosome aneuploidy on cellular physiology and adaptation to stress
Cells and organisms possess enormous ability to adapt to environmental and genetic perturbations. Our recent work demonstrates that aneuploidy is a form of genetic variation that is induced by stress through inaccurate mitosis and leads to phenotypic variation fueling rapid stress adaption. The ability of aneuploidy to confer large phenotypic effects is due to its profound impact on gene expression at both the transcriptome and proteome levels. These findings provide insights into the role of chromosome instability and copy number variation in cancer progression and cellular evolution.
Carl Icahn Lab 101 · 4:15 p.m.– 5:15 p.m.