Events - Daily
|Monday, February 04|
Ariel Amir, Harvard, Bacterial growth: defects, elasticity and plasticity
Bacterial cells have rigid walls, which define their shape, and enable them to hold high internal pressure. While much is known about cell wall chemistry, the mechanisms controlling its growth remain elusive. The processes leading to the cylindrical shape of many bacteria are only now being unraveled. Recent experiments discovered that new cell wall is added by complexes running at constant velocity around the cell circumference, reminiscent of the motion of defects in crystals. By applying a condensed matter approach to this problem and modeling these complexes as edge dislocations, we find coupling between mechanical stresses and cell wall dynamics. Moreover, I will show that the cell wall deformations can be elastic (reversible) or plastic (irreversible), depending on the timescales over which the force is applied. I will corroborate these predictions experimentally by observing the growth of a single bacterium in a microfluidic device, using the flow to control the external force.
Joseph Henry Room, Jadwin Hall · 12:00 p.m.– 1:00 p.m.
David Roth, U Penn, Structural variants in the genome resulting from VDJ recombination errors and from gene therapy
David B. Roth, MD, PhD
Simon Flexner Professor and Chair
Department of Pathology & Laboratory Medicine
My lab has developed novel genomewide approaches to identifying somatic structural variants (translocations, large deletions, etc) arising in lymphomas and as a result of nuclease induced gene disruption or gene targeting.
I will discuss our recent progress.
Carl Icahn Lab 101 · 4:15 p.m.– 5:15 p.m.