Justin Sonnenburg, Stanford University, Deconstructing the intestinal microbiota to reveal mechanisms
The Sonnenburg lab investigates the principles that underlie microbial community function within the gut. Our overarching goal is to define the mechanisms that connect changes in the gut environment, such as dietary change or presence of a pathogen, to the microbiota’s response and impact on host biology. The lab applies molecular genetic and systems-level tools to intestinal microbiology and uses gnotobiotic mouse models to unravel the complexities of interactions that occur within the gastrointestinal tract. We are currently pursuing a deeper understanding of gut microbiota spatial organization using quantitative image analysis. New pursuits include leveraging synthetic biology to engineer gut symbionts that can record their own life experiences, detect inflammation, or execute site-specific therapeutic delivery. The combined insights from these projects are helping us to explore the vast frontier of microbiota reprogramming, building upon recent success of fecal transplants.
Location: Carl Icahn Lab 101
Date/Time: 12/09/13 at 4:15 pm - 12/09/13 at 5:15 pm
Category: Quantitative & Computational Biology
Department: Lewis-Sigler Institute