Erez Braun, Technion, From Genotype to Phenotype: A Physics Perspective
How order emerges from disorder is one of the fascinating questions in biophysics. I’ll discuss our long-term experimental program aiming to explore the adaptation of cells to unforeseen challenges enabling them to evolve. Along this road, our experiments exposed some intriguing characteristics of gene interactions underlying the genotype-to-phenotype transformation, which are compatible with our understanding of a broad class of complex systems. Starting from experiments that aimed to study population adaptation, we have discovered that some basic concepts of cell biology require re-thinking. The common view that regards the genome as a "program," the environment as an "input signal," and the phenotype as a "logical output" of the cellular "computing device," should be revisited. We will discuss the alternative, more natural view regarding the cell as a flexible dynamical system constrained both by the genome and the environment.
Location: Jadwin Hall 111
Date/Time: 09/30/13 at 12:00 pm - 09/30/13 at 1:00 pm
Department: Lewis-Sigler Institute