John Yates, The Scripps Research Institute, Proteomics and Neurobiology
A component to understanding biological processes involves identifying the proteins expressed in cells as well as their modifications and the dynamics of processes. Several major technologies, but especially mass spectrometry, have benefited from large-scale genome sequencing of organisms. The sequence data produced by these efforts can be used to interpret mass spectrometry data of proteins and thus enables rapid and large-scale quantitative analysis of protein data from experiments. We’ve developed methods to stable isotope label mice and rats (SILAM) for study of animal models of human diseases. Recently we’ve been applying SILAM together with mass spectrometry based methods to the study of brain function and disease. Application of these methods to the study of Alzheimer’s mouse models, depression and schizophrenia will be described as well as the use of animal labeling to measure protein longevity.
Dr. Yates is the Ernest W. Hahn Professor in the Department of Chemical Physiology and Molecular and Cellular Neurobiology at The Scripps Research Institute. His research interests include development of integrated methods for tandem mass spectrometry analysis of protein mixtures, bioinformatics using mass spectrometry data, and biological studies involving proteomics. He is the lead inventor of the SEQUEST software for correlating tandem mass spectrometry data to sequences in the database and developer of the shotgun proteomics technique for the analysis of protein mixtures. His laboratory has developed the use of proteomic techniques to analyze protein complexes, posttranslational modifications, organelles and quantitative analysis of protein expression for the discovery of new biology. Many proteomic approaches developed by Yates have become a national and international resource to many investigators in the scientific community. Dr. Yates led an NIDCR funded Center to characterize the Saliva proteome and has been involved in an NCRR funded Research Resource Center for the last 15 years and was involved in an NSF funded Science and Technology for 10 years. He has received the American Society for Mass Spectrometry research award, the Pehr Edman Award in Protein Chemistry, the American Society for Mass Spectrometry Biemann Medal, the HUPO Distinguished Achievement Award in Proteomics, Herbert Sober Award from the ASBMB, and the Christian Anfinsen Award from The Protein Society. He was ranked by Citation Impact, Science Watch as one of the Top 100 Chemists for the decade, 2000-2010. He has published almost 700 scientific articles.
Location: Carl Icahn Lab 101
Date/Time: 11/04/13 at 4:15 pm - 11/04/13 at 5:15 pm
Category: Quantitative & Computational Biology
Department: Lewis-Sigler Institute