Lunch seminar: "The Evolution of Demographic Age Trajectories" - Jessica Metcalf(More about event)
Failure to forecast population patterns resulting from increasing longevity led demographers to turn to biology. Evolutionary biology provides specific predictions on aging; the variety of data available provides insights into the genetic mechanisms underlying these patterns. One relatively under-studied selection pressure on age trajectories of mortality is infectious diseases. Because pathogen generation times are generally much shorter than ours, allowing rapid rates of evolutionary change, developing control mechanisms for pathogens is a complex problem. The innovation developed deep in evolutionary history to meet this challenge is the adaptive immune system. This comes with particular costs and outcomes for the right hand side of the mortality trajectory; but also has surprising implications for the left hand side of the mortality trajectory. I outline some of these patterns, and discuss evolutionary constraints on maternal immunity.
Location: 209 Eno Hall
Date/Time: 05/07/12 at 12:30 pm - 05/07/12 at 1:00 pm
Department: Health Grand Challenge