CHM 500A, B, C Responsible Conduct of Research in Chemistry (Half-Term)
Michael T. Kelly
Discussion and evaluation of the role professional researchers play in dealing with the reporting of research, responsible authorship, human and animal studies, misconduct and fraud in science, intellectual property, and professional conduct in scientific relationships. Participants are expected to read the materials and cases prior to each meeting. Successful completion is based on regular attendance and active participation in discussion. This half-term course is designed to satisfy federal funding agencies¿ requirements for training in the ethical practice of scientists. Required for graduate students and post-docs.
CHM 501 Basic Principles of Quantum Mechanics
Garnet K. Chan, Mark A. Watson
Basic QM concepts at a rigorous level appropriate for graduate students in experimental and theoretical physical chemistry, applied physics and engineering. Topics include (i) mathematical formalism of Hilbert spaces and operators in time-independent quantum theory (ii) single-particle QM for bound and unbound states (iii) basic angular momentum theory (iv) exactly soluble systems: harmonic oscillator and hydrogen atom (v) indistinguishable particles (vi) variational theorem (vii) time-independent perturbation theory (viii) time-dependent theory and Fermi's golden rule, and (ix) applications to chemical problems.
CHM 502 Advanced Quantum Chemistry
Herschel A. Rabitz
Traditionally quantum mechanics is presented as the antipode to classical mechanics; as a result, no attempt at reconciliation is made. The primary purpose of the course is to present quantum and classical mechanics in a unified fashion by clarifying only essential differences. We will also see how quantum-mechanical methods can be applied to classical dynamics and how quantum phenomena have classical analogies.
CHM 503 / CBE 524 Introduction to Statistical Mechanics
Roberto Car and Salvatore Torquato
Statistical mechanics provides the basis for understanding the equilibrium and nonequilibrium properties of matter in terms of the microscopic details of molecular interactions and structure. The course aims to provide students with working knowledge of the fundamentals and applications of statistical mechanics.
CHM 504 Molecular Spectroscopy
Chia-Ying Wang and Haw Yang
A survey of atomic and molecular energy levels and the Hamiltonians that describe them. The interaction of radiation with matter, including multiphoton effects and nano-optics. Examples include electronic and nuclear spectroscopy of molecules and crystals, electron spin resonance, microwave spectroscopy, and the uses of lasers in modern spectroscopic research.
CHM 509 / CHM 510 Topics in Physical Chemistry
Herschel A. Rabitz
Topics covered vary from year to year and are selected from the following: state-selected chemical processes; high-resolution spectroscopy; energy transfer and redistribution; laser-induced chemistry; surface chemistry; electronic properties of conjugated polymers; nonlinear optical materials; physical electrochemistry; heterogeneous reaction dynamics; spectroscopy and dynamics of clusters; and chaotic systems.
CHM 511 / MSE 513 / MAE 516 Introduction to Nanotechnology
Michael C. McAlpine
This course will thus cover a broad range of subjects, with particular emphasis on characterization and control of materials at the nanoscale. The focus is on both the techniques necessary for scientific investigations at small dimensions, and the very latest research developments in this rapidly evolving area. Specific topics covered will include fundamentals of nanoscience, processing of nanomaterials, self-assembled nanostructures, bionanotechnology, graphene, nanoelectronics, size-scaling of properties, and nanodevice fabrication and testing. The course will also provide critical practice in scientific writing and presentation.
CHM 512 Chemical Kinetics
Steven L. Bernasek
A survey of chemical kinetics. Kinetic measurements and experimental methods, reaction rate theory, molecular dynamics experiment and theory will be discussed. Both gas phase and condensed phase kinetic studies will be considered.
CHM 517 / MOL 515 / PHY 570 / EEB 517 Method and Logic in Quantitative Biology
Ned S. Wingreen
Close reading of published papers illustrating the principles, achievements, and difficulties that lie at the interface of theory and experiment in biology. Two important papers, read in advance by all students, will be considered each week; the emphasis will be on discussion with students as opposed to formal lectures. Topics include: cooperativity, robust adaptation, kinetic proofreading, sequence analysis, clustering, phylogenetics, analysis of fluctuations, and maximum likelihood methods. A general tutorial on Matlab and specific tutorials for the four homework assignments will be available.
CHM 521 Organometallic Chemistry
To familiarize the student with basic principles of structure and reactivity of transition metal organometallic chemistry.
CHM 522 Advanced Inorganic Chemistry
Paul J. Chirik
A detailed examination of bonding and structure in transition metal complexes will be undertaken. A variety of modern physical methods will be discussed in this context. Chemical reactivity, including ligand substitution reactions, charge transfer reactions and photochemical processes, will be investigated based on electronic structure considerations. Examples will be drawn from the current literature.
CHM 524 Topics in Inorganic Chemistry - Modern Electrochemistry
Andrew B. Bocarsly and Susan K. VanderKam
This course explores the theory and practice of modern techniques in electrochemistry. Physical chemistry of charge transfer is considered, as well as applications in the areas of electroanalytical chemistry and photoelectrochemistry. Key laboratory techniques, such as cyclic voltammetry, chronoamperometry and rotating disk voltammetry are a focus of the course.
CHM 527 / CBE 526 / MSE 526 Surface Science: Processes and Probes
Bruce E. Koel
An introduction to processes at surfaces and interfaces. Experimental methods of surface science. Electron spectroscopy, ion scattering, and scanning probe microscopy. Atomic structure of surfaces and adsorbed layers. Thermodynamics of surface processes. Adsorption and molecular dynamics of gas-surface reactions. Kinetics of adsorption, desorption, diffusion, and reactions. Liquid interfaces. Heterogeneous catalysts. Etching. Film growth and epitaxy. Applications to energy and environmental science and technology.
CHM 529 Topics in Inorganic Chemistry - Symmetry, Diffraction and the Structures of Non-molecular Solids
Robert J. Cava
Topics covered vary from year to year. The subject matter will be selected from among the following, related to the inorganic chemistry of solids: point group and space group symmetry, irreproducible representations, structure-property relations, crystallography, methods in X-ray, neutron and electron diffraction science, the structures of solids and molecules, the electronic structure of molecular and non-molecular solids, the optical, electronic and magnetic properties of molecular and non-molecular solids and their relation to crystal structure.
CHM 530 Synthetic Organic Chemistry
Robert R. Knowles
A mechanism-based course on organic synthesis for advanced undergraduates and beginning graduate students who wish to learn chemical synthesis of organic compounds. Course deals with various classical and modern synthetic methodologies. Particular emphasis is placed on understanding scope, limitations, and selectivity based on the mechanism, with the goal to understand fundamental principles underlying each synthetic method. The knowledge and perspective acquired in this course is expected to provide sufficient foundation to understand and use the research literature in organic synthesis.
CHM 534 Modern Methods for Organic Synthesis
David W. MacMillan and Erik J. Sorensen
This course will expose you to many types of carbon-based molecular structures, the transformations they undergo, and many kinds of chemical reactions and strategies that are important to the field of organic synthesis. Recent advances in asymmetric catalysis, cascade and other complexity-generating structural transformations, and powerful strategies for chemical synthesis that evolved from ideas about the structural origins of important, biologiclaly active molecules such as steriod hormones, cofactors, and alkaloids will be addressed.
CHM 536 Topics in Organic Chemistry - Methods for Complex Organic Synthesis
Paul J. Chirik and Abigail G. Doyle
An in-depth discussion of transition metal-catalyzed reactions commonly used in modern organic synthesis (e.g. cross coupling, olefin metathesis, asymmetric hydrogenation, etc.). Emphasis will be placed on the topic of selectivity (chemo-, regio-, and stereo-) and its mechanistic basis. The historical development, scope, and limitations of the methods are discussed. A prior course in organometallic chemistry (CHM 521) is recommended.
CHM 538 Topics in Biological Chemistry - Chemical Tools to Study Biological Systems
Tom Muir and Mohammad R. Seyedsayamdost
This class emphasizes the use of chemical approaches to investigate and manipulate biological processes at the biochemical, the cellular, and the organismal level. The purpose is to provide chemical biologists with modern chemical methods. The class will then discuss how these methods can be applied to study different biological problems, highlighting important questions in biology. Typically a paper from the current literature will be presented and discussed by the students each class. Grades are based on problem sets, a midterm exam, a literature presentation, and a research proposal.
CHM 539 Introduction to Chemical Instrumentation
The application of instrumentation (chiefly spectrometers) to modern chemical/biochemical research, including materials science and environmental and medicinal chemistry, will be covered. Primary emphasis will be on NMR methods (including data processing and spectrum analysis), along with portions addressing mass spectrometry , X-ray diffraction, IR, UV, and EPR spectroscopy, and chiroptical techniques. The integrated nature of using various instrumental methods for identification and characterization of molecular structure and dynamics will be emphasized. Recommended for graduate students, and junior and senior undergraduates.
CHM 541 / QCB 541 Chemical Biology II
Tom Muir and Joshua D. Rabinowitz
A chemically and quantitatively rigorous treatment of metabolism and protein synthesis, with a focus on modern advances and techniques. Topics include metabolic pathways and their regulation; metabolite and flux measurement; mathematical modeling of metabolism; amino acid, peptide and protein chemistry; protein engineering and selected applications thereof.
CHM 542 Principles of Macromolecular Structure: Protein Folding, Structure and Design
Michael H. Hecht
This course will be taught from the scientific literature. We will begin the semester with several classic papers on protein folding. As the semester progresses, we will read about protein structure, stability, and folding pathways. The latter part of the semester will focus on recent papers describing new research aimed toward the construction of novel proteins from "scratch." These papers will cover topics ranging from evolution in vitro to computational and rational design. The course will end by discussing the possibility of creating artificial proteomes in the laboratory, and further steps toward synthetic biology.
CHM 543 Advanced Topics in Structural Biology
Clarence E. Schutt
Structural biology of human diseases. A critical discussion of protein structures of medical interest such as antibodies, histocompatibility complexes, growth factors, receptors, T-cell activation, G-coupled receptors, viruses, and bacterial toxins. The structural basis of signal transduction is treated in terms of high-resolution crystal structures of kinases and phosphatases. Special emphasis is placed on methods used to obtain and interpret results by X-ray crystallography.
CHM 544 Metals in Biology
Dorothea Fiedler and John T. Groves
Life processes depend on over 25 elements whose bioinorganic chemistry is relevant to the environment (biogeochemical cycles), agriculture, and health. CHM 544 surveys the bioinorganic chemistry of the elements. In-depth coverage of key transition metal ions including manganese, iron, copper, and molybdenum focuses on redox roles in anaerobic and aerobic systems and metalloenzymes that activate small molecules and ions, including hydrogen, nitrogen, nitrate, nitric oxide, oxygen, superoxide, and hydrogen peroxide. Appreciation of the structure and reactivity of metalloenzyme systems is critical to understanding life at the molecular level.
CHM 550 / MOL 550 Contemporary Problems in Molecular Biophysics
The course will analyse in depth the chemical, physical, and mathematical principles underlying the intermolecular interactions of macromolecules. The background, interdisciplinary context, and current understanding of the topic will be developed from close, directed readings of classical and contemporary articles from the research literature.