The Integration of Chemistry and Biology to Seed a Next Generation of Malaria and Tuberculosis Therapeutics
Professor Erik J. Sorensen and Dr. Joel S. Freundlich are leading a chemistry-driven effort to seed the discovery of novel antitubercular and antimalarial agents. Key to their effort is the development of novel synthetic methodology to efficiently construct complex organic molecules, both natural products and their designed analogs, that have the desired biological activity. Through extensive biology-based collaborations, both at Princeton University and abroad, their goal is to detail the in vitro and in vivo efficacy of these small molecules while thoroughly understanding their mechanism of action. The end result of this research should be both novel biological targets and facilely accessible small molecules that modulate them to achieve the desired antitubercular and/or antimalarial activity.
PIs
Joel S. Freundlich
Department of Chemistry
