Foreign Minister Kasuri was born in Lahore in 1941. He graduated with honors from Punjab University in 1961 with a Bachelor of Arts and did his tripos at Cambridge University in 1963. He went on to pursue post-graduate studies in Public Administration and Political Science at Oxford University, and was then called to the Bar from Gray's Inn, London. He has lectured in the South Asian and Political Science faculties at the American University, Washington University, George Mason University, University of Pennsylvania, Duke University, and University of California at Berkeley.

In 1972 Kasuri served as a Special Envoy of the Government of Pakistan to the UK and US. He was elected in 1990 as the Secretary General of People's Democratic Alliance (PDA). Later he was appointed Federal Minister for Parliamentary Affairs in the Interim Government and elected as Member of the National Assembly. Kasuri has served on several government committees, including the Member National Assembly’s Standing Committee on Foreign Relations and acted as Chairman of National Assembly's Standing Committee on Information & Media Development.