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In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a Princeton University research team has unraveled a mystery about how these tumors take root.

Alexander Smits and Richard Miles, professors of mechanical and aerospace engineering, and Christodoulos Floudas, professor of chemical and biological engineering, have been elected as 2011 members of the National Academy of Engineering.

Using mathematical concepts, Princeton researchers have developed a method of discovering new drugs for a range of diseases by calculating which physical properties of biological molecules may predict their effectiveness as medicines. The technique already has identified several potential new drugs that were shown to be effective for fighting strains of HIV by researchers at Johns Hopkins University.