Biophysics Seminar Series - Jané Kondev (Brandeis U.) Regulation of transcriptional noise in bacteria
Genes encoded in the cell's DNA are read by RNA polymerase and converted into messenger RNA in the process of transcription. The number of different molecular players involved in this process is typically small leading to noise in the transcriptional output, whereby genetically identical cells produce different amounts of messenger RNA when exposed to identical environmental conditions. In this talk I will discuss experiments that measure this cell-to-cell variability of transcriptional outputs and simple models that have been put forward in response to them. In particular, I will describe how a combination of quantitative experiments and theory can be used as a tool for testing different molecular mechanisms of transcriptional regulation in cells. These ideas will be illustrated using the lac and ribosomal RNA operons in E.coli as case studies.
Location: Joseph Henry Room
Date/Time: 03/26/12 at 11:45 am - 03/26/12 at 1:00 pm
Lunch at 11:45 am, seminar begins at 12.
Category: Biophysics Seminar