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Seminar 5/2/2012 - Joao Pedro Conde, The Technical University of Lisbon: Lab-on-Chip Detection of Biomolecules with Integrated Sensors

Abstract: Detection of bioanalytes (such as DNA, proteins, cells, metabolic products) is a central aspect in medicine, food safety, environmental control, etc. We will start by describing our research in two miniaturized transducer concepts. The first involves the use of thin-film silicon photodiodes as optical/electrical transducers and the second involves the use of the measurement of streaming currents in micro/nanochannels as a surface charge/electrical transducer. These transducers are integrated with molecular recognition element able to specifically capture the bioanalyte of interest. We will discuss the strategies that we use for this integration, and how the characteristics of the biosensor relate to the sensitivity of the detection. In addition, we will briefly describe on-going research integrating these sensors in cell-chips.

To take full advantage of the miniaturization of the biosensor, it is crucial in addition to address two other issues: (i) fluidic handling from sample to sensor; (ii) consideration of the interfering effects of the often chemically and physically complex biological sample matrix. We will use our work on the detection of a toxin (ochratoxin A, OTA) produced by fungi that contaminate several sources of food and drink as a case study of an integrated lab-on-a-chip analytical system.

All seminars are held on Wednesdays from 12:00 noon-1:00 p.m. in the Bowen Hall Auditorium Room 222. A light lunch is provided at 11:30 a.m. in the Bowen Hall Atrium immediately prior to the seminar.

Location: Bowen Hall Auditorium

Date/Time: 05/02/12 at 12:00 pm - 05/02/12 at 1:00 pm

Category: PRISM/PCCM Seminar Series

Department: PRISM