The Princeton Physical Sciences-Oncology Center (PPS-OC) was established September, 2009 under a five-year, $15 million dollar award from the National Cancer Institute. The Princeton-led PS-OC is one of a network of twelve such centers established at some of the country's leading research institutions. The mission of the Princeton PS-OC is to explore the explosive evolution of cancer under stress. Grounded in a physics-based approach, and utilizing a cross-disciplinary team of physicists, engineers, oncologists, chemists and biochemists, the PPS-OC investigates the unsolved and deadly problem of the re-emergence of resistant cancer cells. Research conducted by the PPS-OC addresses critical questions such as: How does evolution lead to metastasis and drug resistance, and how can we use evolution to change cancer outcomes?