The selected publications listed below were supported by Award Number U54CA143803 from the National Cancer Institute, National Institutes of Health. The content of each publication is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.
Physical Sciences - Oncology Centers Network, A Physical Sciences Network Characterization of Non-Tumorigenic and Metastatic Cells, Sci Rep. 2013 Apr 25;3:1449. doi: +10.1038/srep01449.
Jiao, Y and Torquato, S, Evolution and Morphology of Microenvironment-Enhanced Malignancy of Three-Dimensional Invasive Solid Tumors, Physical Review E, 87, 052707 (2013)
Hedayati M, Thomas O*, Abubaker-Sharif B, Zhou H, Cornejo C, Zhang Y, Mihalic J, Gruettner C, Westphal F, Geyh A, DeWeese TL, Ivkov R. The effect of cell-cluster size on intracellular nanoparticle-mediated hyperthermia: Is it possible to treat microscopic tumors?, Nanomedicine-UK, 8, 29-41 (2013)
Yu Zeng, Dana Wodzenski, Dong Gao, Takumi Shiraishi, Naoki Terada, Youqiang Li, Donald J. Vander Griend, Jun Luo, Chuize Kong, Robert H. Getzenberg, Prakash Kulkarni. Stress response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing. Cancer Research, 2013
Roy S, Gascard P, Dumont N, Zhao J, Pan, D, Petrie S, Margeta, M, and Tlsty, TD. Rare somatic cells from human breast tissue exhibit extensive lineage plasticity, Proc Natl Acad Sci. March 4, 2013. doi:10.1073/pnas.1218682110.] PMID: 23487770
Fordyce CA, Patten KT, Fessenden TD, DeFilippis R, Hwang ES, Zhao J, and Tlsty TD. Cell-extrinsic consequences of epithelial stress: Activation of protumorigenic tissue phenotypes, Breast Cancer Res. 14:R155, 2012. PMID: 23216814.
Lopez-Diaz, FJ, Gascard, P, Balakrishnan S, Zhao, J, del Rincon, SV, Spruck, C, Tlsty, TD, and Emerson, BM. Coordinate Transcriptional and Translational Repression of p53 by TGFβ1 Impairs the Stress Response. Molecular Cell, Volume 50, Issue 4, 552-564, 23 May 2013
W Reisner, JN Pedersen and RH Austin, DNA Confinement in Nanochannels: Physics and Biological Applications, Reports on Progress in Physics, 75 106601 (2012)
Liu L, Duclos G, Sun B, Lee J, Wu A, Kam Y, Sontag E, Stone H, Sturm JC, Gatenby R, Austin RH. Minimization of thermodynamic costs in cancer cell invasion. Proceedings of National Academy of Sciences, vol. 110, 1686-1691 (2013).
"Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics." Nancy Dumont, Bob Liu, Rosa Anna DeFilippis, Hang Chang, Joseph T. Rabban*, Anthony N. Karnezis, Judy A. Tjoe, James Marx, Bahram Parvin and Thea D. Tlsty. Neoplasia, Volume 15 Number 3 March 2013 pp. 249– 262.
"Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics," Nancy Dumont, Bob Liu, Rosa Anna DeFilippis, Hang Chang, Joseph T. Rabban*, Anthony N. Karnezis, Judy A. Tjoe, James Marx, Bahram Parvin and Thea D. Tlsty. Neoplasia, Volume 15, Number 3 March 2013 pp. 249– 262
" Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells." Tien J., Truslow J.G., & Nelson C.M. (2012) PLOS ONE, 7: e45191.
"The Effect of Cluster-cell Size on Intracellular nanoparticle-mediate Hyperthermia: Is it Possibe to Treat Microscopic Tumors? Hedayati M, Thomas O, Abubaker-Sharif B, Zhou H, Zhang Y, Cornejo C, Wabler M, Mihalic J, Gruetner C,Westfasll F, Geyh A, DeWeese TL, Ivkov R. doi:10.2217/NNM.12.98. Future Medicine, 2012.
"Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer." Kim JJ, Bo Yin B, Christudass CS, Terada N, Rajagopalan K, Fabry B, Danielle Y. Lee DY, Shiraishi T, Robert H. Getzenberg RH, Veltri RW, An SS, & Mooney SM. J Cellular Biochemistry 2012
"Deterministic separation of cancer cells from blood at 10 ml/min,” Kevin Loutherback, Joseph D’Silva, Liyu Liu, Amy Wu, Robert H. Austin, James C. Sturm. Amer. Inst. Phys. Advances vol 2, 042107 (2012)
“Physics of cancer propagation: A game theory perspective,” Chris Cleveland, David Liao, and Robert Austin, AIP Advances 2, 011202 (2012)
“Toy Story: What I have learned from playing with toys about the physics of living cells,” R. Austin, Proc. SPIE 7929, 792902 (2011); doi:10.1117/12.882723.
"CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues." DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD. Cancer Discov. 2012, 2:826-39. PMID: 22777768
"Generalized Principles of Stochasticity Can be Used to Control Dynamic Heterogeneity." David Liao, Luis Estévez-Salmerón, and Thea D. Tlsty. Phys. Biol. x (2012) y (22pp) (Expected online publication: November 2012, print: December 2012).
"Conceptualizing a Tool to Optimize Therapy Based on Dynamic Heterogeneity." David Liao, Luis Estévez-Salmerón, and Thea D. Tlsty. Physical Biology x (2012) y (27pp) (Expected online publication: November 2012, print: December 2012.
"Applications of Microfluidics in Stem Cell Biology." Qiucen Zhang and Robert H. Austin, BioNanoScience 2012, DOI: 10.1007/s12668-012-0051-8.
"Physics of Cancer: The Impact of Heterogeneity." Zhang, Qiucen, and Robert H. Austin, Annual Review of Condensed Matter Physics 3 (2012): 363-382. Project 1
"Physics of Cancer." Robert H. Austin and Bernard S. Gerstman: Preface, AIP Advances 2, 010901 (2012); (3 pages). Project 1
"Diversity of Dynamics and Morphologies of Invasive Solid Tumors," Y. Jiao and S. Torquato, AIP Advances, 2, 011003 (2012)
Ben-Jacob E, Coffey DS and Levine H. Bacterial Survival Strategies Suggest Rethinking Cancer Cooperativity. Trends in Microbiology. Trends in Microbiology, 2012; 20(9): 403-10.
"Anomalous Spatial Redistribution of Competing Bacteria Under Starvation Conditions," Guillaume Lambert, David Liao, Saurabh Vyawahare, Robert H. Austin, Journal of Bacteriology, 193:1878-1883 (2011).
"The Goldilocks Principle and Antibiotic Resistance in Bacteria", Quicen Zhang, Kristelle Robin, David Liao, Guillaume Lambert, Robert H. Austin, Mol. Pharm., 2011 Dec 5;8(6):2063-8.
"Probing the Invasiveness of Prostate Cancer Cells in a 3D Microfabricated Landscape", Liu L, Sun B, Pedersen J, AwYong KM, Getzenberg RH, Stone HA, Austin RH, J Cell Biochem, Aug:112(8):2125-37.
"Adaptive Energy Selective Active Contour with Shape Priors for Nuclear Segmentation and Gleason Grading of Prostate Cancer", Ali S, Veltri R, Epstein JI, Christudass C, Madabhushi A, MICCAI (1) 2011: 661-669.
"Nuclear morphometry, nucleomics and prostate cancer progression." Veltri RW, Christudass CS, and Isharwal S. Asian Journal of Andrology., doi:10.1038/aja.2011.148.
"Cardinal Multiridgelet-based Prostate Cancer Histological Image Classification for Gleason Grading." Yoon H-J, Li CC, Christudass C, Veltri R, Epstein JI, and Zhang Z. BIBM, 2011 (Accepted).
"Changing the Energy Habitat of the Cancer Cell in Order to Impact Therapeutic Resistance," Getzenberg RH, Coffey DS, Mol Pharm, 2011 Dec 5;8(6):2089-93.
"Quantitative Characterization of the Microstructure and Transport Properties of Biopolymer Networks." Y. Jiao and S. Torquato. Physical Biology. In press. Core 2, Project 4
"Whole transcriptome RNAseq analysis from minute amount of total RNA." Muhammad A. Tariq, Hyunsung J. Kim, Olufisayo Jejelowo, Nader Pourmand. Nucleic Acids Res. 2011 Oct;39(18):e120. Core 3
"Spatial Organization and Correlation of Cell Nuclei in Brain Tumors," Y. Jiao, H. Berman, T.R. Kiehl and S. Torquato, PLoS One, 2011;6(11)
"Emergent Properties from a Cellular Automaton Model for Invasive Tumor Growth in Heterogeneous Environment," Y. Jiao and S. Torquato, PLoS Computational Biology, Dec 2011
"Acceleration of Emergence of Bacterial Antibiotic Resistance in a Microenvironment," Qiucen Zhang, Kristelle Robin, Guillaume Lambert, David Liao, Hyunsung Kim, Nader Pourmand, Robert H. Austin, Science. 2011 Sep 23;333(6050):1764-7
"An analogy between the evolution of drug resistance in bacterial communities and malignant tissues," Guillaume Lambert, Luis Estevez-Salmeron, Steve Oh, David Liao, Beverly M. Emerson, Thea D. Tlsty and Robert H. Austin, Nature Cancer Reviews 2011 May;11(5):375-82
"Protein Folding and the Order/Disorder Paradox," Kulkarni P, Rajagopalan K, Yeater D and Getzenberg RH., Journal of Cellular Biochemistry, 2011 Jul;112(7):1949-52
"Resistance to paclitaxel increases the sensitivity to other microenvironmental stresses in prostate cancer cells," Li Y, Zeng Y, Mooney SM, Yin B, Mizokami A, Namiki A, and Getzenberg, RH., J Cell Biochem, 2011 Aug;112(8):2125-37
"Collective Escape of Chemotactic Swimmers Through Microscopic Ratchets," Guillaume Lambert, David Liao, Robert H. Austin, Rhys. Rev. Lett., 104.168102 (2010)
"An Introduction to Micro-ecology Patches", Robert H. Austin, Chih-kuan Tung, Guillaume Lambert, David Liao and Xiuqing Gong, Chem. Soc. Rev., 39, 1049-1059. 2010
"The Anti-lotus Leaf Effect in Nanohydrodynamic Bump Arrays", Keith Morton, Ophelia Tsui, Chih-Kuan Tung, James Sturm, Stephen Chou, Robert H. Austin, New J. Phys. 12 085008 (2010)
"A Microfluidic Device for Continuous Cancer Cell Culture and Passage with Hydrodynamic Forces", Liyu Liu, Kevin Loutherback, David Liao, David Yeater, Guillaume Lambert, Andre Estevez-Torres, James C. Sturm, Robert H. Getzenberg and Robert H. Austin, Lab on a Chip DOI: 10.1039/c003509b (2010).
"Improved performance of deterministic lateral displacement arrays with triangular posts," Kevin Loutherback, Kevin Chou, Jonathan Newman, Jason Puchalla, Robert Austin, James Sturm. Microfluidics and Nanofluidics (December 2010), 9 (6), pg. 1143-1149
"Ultrasensitive mycotoxin detection by sting sensors," Actis P, Jejelowo O, Pourmand N., Biosens Bioelectron, 2010 Oct 15;26(2):333-7
"Deterministic Microfluidic Ratchet", Kevin Loutherback, Jason Puchalla, Robert H. Austin and James C. Sturm, Phys Rev Lett 102:10.1103/PhysRevLet.1102.45301 (2009).