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Lewis-Sigler Institute for Integrative Genomics



Acting Director

Ned S. Wingreen

Associate Director

Ned S. Wingreen


Peter Andolfatto, also Ecology and Evolutionary Biology

William Bialek, also Physics

David Botstein, also Molecular Biology

Thomas Gregor, also Physics

Coleen T. Murphy, also Molecular Biology

Joshua D. Rabinowitz, also Chemistry

Joshua W. Shaevitz, also Physics

Stanislav Y. Shvartsman, also Chemical and Biological Engineering

Mona Singh, also Computer Science

John D. Storey, also Molecular Biology

Shirley M. Tilghman, Molecular Biology, Woodrow Wilson School

Olga G. Troyanskaya, also Computer Science

Eric F. Wieschaus, also Molecular Biology

Ned S. Wingreen, also Molecular Biology

Associated Faculty

Bernard Chazelle, Computer Science

John Groves, Chemistry

Lewis-Sigler Fellow

Anastasija Baryshnikova

Chase P. Broedersz

Andrew M. Leifer

Benjamin B. Machta

Megan N. McClean

Marcus B. Noyes

The Lewis-Sigler Institute for Integrative Genomics was established with a mandate to develop novel approaches to the study of biology in a post-genome-sequence era. The institute comprises a multidisciplinary group of scientists and students working at the interface of biology and the more quantitative sciences and computation. This is meant to include, among others, the fields of genomics, biophysics, computational neurobiology, systems biology, population biology and quantitative genetics, molecular evolution, computational biology, and microbial interactions. Unlike other genomics institutes, the Lewis-Sigler Institute does not focus on generating large amounts of sequence data. Rather, the focus is to extract from these enormous amounts of data an understanding of how biological systems organize and integrate complex processes.

The institute consists of 12 to 15 research groups. All tenured and tenure-track faculty in the institute have appointments in one of the University's departments; among them are molecular biology, ecology and evolutionary biology, physics, chemistry, computer science, chemical and biological engineering, and potentially others.

The institute's mandate includes innovation in teaching, specifically the teaching of biology integrated fully with the more quantitative sciences, mathematics, and computation. Education is carried out formally through the undergraduate certificate and graduate Program in Quantitative and Computational Biology (QCB).

In sum, the Lewis-Sigler Institute is a hub of intellectual activity for quantitatively oriented biologists at every level: undergraduate, graduate, and faculty.