Wilson College

The Garcia laboratory is focused on developing novel mass spectrometry based proteomic methodologies for quantitatively characterizing changes in protein expression and post-translational modification state within a given proteome during significant biological events or in response to external perturbation.  Our goal is to utilize large-scale proteomic data to improve our understanding of biological processes at the molecular level.  We currently employ Bottom up (sequencing of small peptides), Middle down (sequencing of large polypeptides) and Top down (sequencing of intact proteins) proteomic strategies and allied techniques to achieve our aims.   Application of our proteomic technology spans several areas of molecular biology, but one main interest is described below.

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