Interstate 81

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Interstate 81 marker

I-26 / US-23 near Kingsport, TN
I-77 near Wytheville, VA
I-64 from Lexington, VA to Staunton, VA
I-70 at Hagerstown, MD
I-76 / Penna. Tpk. at Carlisle, PA
I-78 at Union Township, PA
I-80 near Hazleton, PA
I-84 near Scranton, PA

Main route of the Interstate Highway System
Main • Auxiliary • Business

Interstate 81 (abbreviated I-81) is an Interstate Highway in the eastern part of the United States. Its southern terminus is at Interstate 40 in Dandridge, Tennessee; its northern terminus is on Wellesley Island (near Fishers Landing, New York) at the Canadian border, where the Thousand Islands Bridge connects it to Highway 401, the main freeway connecting Windsor-Detroit and Toronto to Montreal.

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