Urea cycle

related topics
{acid, form, water}
{disease, patient, cell}
{language, word, form}

The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932). In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.

Contents

Function

Organisms that cannot easily and quickly remove ammonia usually have to convert it to some other substance, like urea or uric acid, which are much less toxic. Insufficiency of the urea cycle occurs in some genetic disorders (inborn errors of metabolism), and in liver failure. The result of liver failure is accumulation of nitrogenous waste, mainly ammonia, which leads to hepatic encephalopathy.

Reactions

The urea cycle consists of five reactions: two mitochondrial and three cytosolic. The cycle converts two amino groups, one from NH4+ and one from Asp, and a carbon atom from HCO3, to the relatively nontoxic excretion product urea at the cost of four "high-energy" phosphate bonds (3 ATP hydrolyzed to 2 ADP and one AMP). Orn is the carrier of these carbon and nitrogen atoms.

1 L-ornithine
2 carbamoyl phosphate
3 L-citrulline
4 argininosuccinate
5 fumarate
6 L-arginine
7 urea
L-Asp L-aspartate
CPS-1 carbamoyl phosphate synthetase I
OTC Ornithine transcarbamylase
ASS argininosuccinate synthetase
ASL argininosuccinate lyase
ARG1 arginase 1

Full article ▸

related documents
Protein kinase
GTPase
Gram staining
Protein biosynthesis
Ketone
Cytochrome
Barium
Trypsin
Peroxide
Solution
Nitrate
Calcite
Hydrate
Glycosidic bond
Amide
Racemic mixture
Vacuole
Rubidium-strontium dating
Evaporation
Phosphorylation
Geochemistry
Methylation
Centrosome
Chemical compound
Polysaccharide
Alanine
Nutrient
Holmium
Francium
Superoxide