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I am a CNRS Researcher in the Laboratoire Jean Perrin at Université Pierre et Marie Curie - Paris 6 (a member of Sorbonne Universités) in Paris, France.

I have broad research interests in the field of biological physics. I perform both analytical work and numerical simulations, and I enjoy collaborating with experimentalists.
I am currently working on various aspects of the link between functions and constraints in multi-protein complexes, with projects both at the microscopic scale and at the population scale.

Until January 2016, I was a Postdoctoral Research Fellow in the Biophysics Theory Group of the Lewis-Sigler Institute for Integrative Genomics at Princeton University, in Princeton, NJ, USA.
The Principal Investigators of this group are Professors Ned Wingreen, William Bialek and Curtis Callan.
I held a Cross-Disciplinary Fellowship from the Human Frontier Science Program.
My post-doctoral research focused on self-assembled multi-protein complexes. I grew especially interested in the constraints that stem from interactions: two proteins that interact together need to be complementary both in shape and in terms of physico-chemical interactions. Because of this, they co-evolve, which leads to rugged fitness landscapes, and to correlations between sequences. These themes are central in my current research.

I obtained my PhD at the laboratoire Matière et Systèmes Complexes (Complex Matter and Complex Systems laboratory) of Université Paris-Diderot, Paris 7 and CNRS, in Paris, France.
I was advised by Professor Jean-Baptiste Fournier.
My PhD research focused on the theoretical physics of complex biological membranes, in particular on membrane-mediated interactions between proteins embedded in cell membranes, and on the impact of local chemical heterogeneities on cell membranes.

Contact:

Address: Room 510 - Towers 32-33, 5th floor
Université Pierre et Marie Curie, 4 place Jussieu
75005 Paris, France

Email: anne-florence.bitbol AT upmc DOT fr