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Research interests

I have broad research interests in the physics of biological systems.
I am interested in understanding living organisms and living matter thanks to physics, especially statistical physics, but also thanks to other quantitative approaches. I perform both analytical work and numerical simulations, and I enjoy collaborating with experimentalists.

I am currently mainly working on topics related to evolution, from the molecular scale to the population scale. The first one deals with the sequence-function relationship in proteins. The second one is about the evolution of antibiotic resistance.
These themes are inspired by my post-doctoral research, which I conducted at Princeton. During my postdoc, I focused on various aspects of the link between functions and constraints in self-assembled multi-protein complexes. I grew especially interested in the constraints that stem from interactions: two proteins that interact together need to be complementary both in shape and in terms of physico-chemical interactions. Because of this, they co-evolve, which leads to rugged fitness landscapes, and to correlations between sequences.

My PhD research dealt with the theoretical physics of complex biological membranes, which surround each of our cells. These membranes contain various inclusions, in particular membrane proteins, which play crucial biological roles. In addition, it is through the membrane that a cell interacts with its environment.
My thesis focused on some generic effects of the presence of one or two membrane inclusions, or of a local chemical change of the environment of the membrane.